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Formin-g the cytoarchitecture of the heart in health and disease

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Starts:13:00 4 Nov 2014
Ends:14:00 4 Nov 2014
What is it:Seminar
Organiser:Faculty of Life Sciences
Who is it for:University staff, Current University students
Speaker:Elisabeth Ehler
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  • In category "Seminar"
  • In group "(FLS) Tissue Systems Seminar Series"
  • By Faculty of Life Sciences

This seminar is part of the Tissue Systems seminar series. We are investigating the assembly of multiprotein complexes that are essential for heart function, such as the myofibrils and the specialised type of cell-cell contact, the intercalated disc, during heart development and any changes in the diseased heart, in particular in dilated cardiomyopathy (DCM). In recent years a major focus of the lab has been on members of the formin family of actin regulating proteins. We have identified a muscle specific isoform of FHOD3, which is required for myofibril maintenance and which is reduced in DCM. Another formin, FHOD1, is mainly found at intercalated discs and is increased in DCM. These results highlight a role for these formins in heart tissue and also show that formins are differentially regulated as far as their subcellular distribution and response to stress is concerned.

Speaker

Elisabeth Ehler

Organisation: King's College London

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Lecture Theatre
Michael Smith Building
Manchester

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Rachel Lea

0161 275 5360

rachel.lea@manchester.ac.uk

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