Formin-g the cytoarchitecture of the heart in health and disease
| Dates: | 4 November 2014 |
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| Times: | 13:00 - 14:00 |
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| What is it: | Seminar |
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| Organiser: | Faculty of Life Sciences |
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| Who is it for: | University staff, Current University students |
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| Speaker: | Elisabeth Ehler |
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This seminar is part of the Tissue Systems seminar series. We are investigating the assembly of multiprotein complexes that are essential for heart function, such as the myofibrils and the specialised type of cell-cell contact, the intercalated disc, during heart development and any changes in the diseased heart, in particular in dilated cardiomyopathy (DCM). In recent years a major focus of the lab has been on members of the formin family of actin regulating proteins. We have identified a muscle specific isoform of FHOD3, which is required for myofibril maintenance and which is reduced in DCM. Another formin, FHOD1, is mainly found at intercalated discs and is increased in DCM. These results highlight a role for these formins in heart tissue and also show that formins are differentially regulated as far as their subcellular distribution and response to stress is concerned.
Speaker
Elisabeth Ehler
Organisation: King's College London
Travel and Contact Information
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Lecture Theatre
Michael Smith Building
Manchester
