Pressure-driven cell movement through a 3D matrix
| Dates: | 16 February 2015 |
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| Times: | 12:00 - 13:00 |
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| What is it: | Seminar |
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| Organiser: | Faculty of Life Sciences |
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| Who is it for: | University staff, Current University students |
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| Speaker: | Ryan Petrie |
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Fibroblasts migrating in three-dimensional (3D) matrix change how they move in response to the elastic behavior of the material surrounding them. Linearly elastic environments, such as dermis or fibroblast-derived matrix, cause cells to switch their leading protrusions from fan-shaped lamellipodia to blunt, cylindrical protrusions termed "lobopodia". Lobopodial protrusions use intracellular pressure to extend their leading edge in place of the actin polymerization and Brownian ratchet mechanisms classically associated with lamellipodia. Lobopodia-bearing fibroblasts increase cytoplasmic pressure by using polarized actomyosin contractility to pull the nucleus forward like a piston. The compartmentalized pressure generated by the nuclear piston is required for the rapid migration of fibroblasts in a 3D matrix. Future work will establish how intracellular pressure-based mechanisms contribute to cancer cell invasion and metastasis.
Speaker
Ryan Petrie
Role: Research Fellow
Organisation: Laboratory of Cell and Developmental Biology NIDCR/NIH
Travel and Contact Information
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1.006
AV Hill Building
Manchester
