BEGIN:VCALENDAR
PRODID:-//Columba Systems Ltd//NONSGML CPNG/SpringViewer/ICal Output/3.3-
 M3//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20201118T115704Z
DTSTART:20201215T130000Z
DTEND:20201215T140000Z
SUMMARY:Centre for Primary Care & Health Services Research Seminar: Dr Ky
 m Snell - External validation of existing prediction models for pre-ecla
 mpsia and development of new models using an IPD meta-analysis
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}q1au-khncoy
 z9-bilm3r
DESCRIPTION:At this seminar\, our external speaker Dr Kym Snell\, Lecture
 r in Biostatistics at Keele University\, will present a talk titled “Ext
 ernal validation of existing prediction models for pre-eclampsia and dev
 elopment of new models using an individual participant data (IPD) meta-a
 nalysis”.\n\n\nSummary:\nPre-eclampsia is a condition that can occur in 
 the second half of pregnancy and is a leading contributor to maternal an
 d perinatal mortality and morbidity. Accurately predicting which women a
 re at high risk of pre-eclampsia would enable effective antenatal care t
 o reduce the risk of developing pre-eclampsia and the adverse outcomes a
 ssociated with it. Over 130 models have been developed for predicting pr
 e-eclampsia\, yet few have been externally validated and none are curren
 tly recommended by guidelines.\n\nThe International Prediction of Pregna
 ncy Complications (IPPIC) collaborative network consists of 125 collabor
 ators from 25 countries\, many of whom have contributed individual parti
 cipant data (IPD) from primary studies. The IPPIC database contains IPD 
 from over 70 studies and over 5 million women with information on clinic
 al characteristics\, biochemical markers\, ultrasound markers as well as
  maternal and offspring complications. \nIn this talk I will discuss how
  we externally validated existing prediction models\, and developed and 
 validated new prediction models for pre-eclampsia using an IPD meta-anal
 ysis approach with the IPPIC data. The talk is intended for a wide audie
 nce\, and will discuss issues such as missing data\, meta-analysis metho
 ds for summarising predictive performance\, dealing with between-study h
 eterogeneity\, and examining clinical utility.\n\n\n\nFor Zoom details\,
  please email: CPC.seminar.series@manchester.ac.uk\n\n
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:via Zoom
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END:VCALENDAR