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PRODID:-//Columba Systems Ltd//NONSGML CPNG/SpringViewer/ICal Output/3.3-
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VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20190510T132450Z
DTSTART:20190513T130000Z
DTEND:20190513T140000Z
SUMMARY:Spatial stochastic models of intracellular dynamics in dilute and
crowded conditions
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}q1io-jvi44i
01-hwtur7
DESCRIPTION:Join us for this research seminar\, part of the Mathematics i
n the life sciences seminar series.\n\nStochastic effects in biochemical
reaction systems are commonly studied by means of the Reaction-Diffusio
n Master equation (RDME). The RDME is computationally efficient and has
the advantage of being amenable to analysis. However the RDME assumes po
int particle interactions\, i.e. dilute conditions. This presents a prob
lem because the intracellular environment can be highly crowded with up
to 40% of its volume being occupied by various macromolecules. In this t
alk I will discuss our recent work showing how the RDME can be modified
to take into account volume-excluded interactions. This can be solved in
certain conditions yielding explicit expressions for the dependence of
reactant number fluctuations on the available volume fraction of space.
I will also discuss how one can use the modified RDME to derive coupled
nonlinear partial differential equations which describe molecular moveme
nt in highly heterogeneous crowded environments and which hence offer a
realistic alternative to the classical diffusion equation. All results w
ill be contrasted with those obtained from Brownian dynamics.
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:Lecture theatre E\, Zochonis Building\, Manchester
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