DCS Next-Gen Seminar with Zoi Diamantopoulou "The metastatic spread of breast cancer accelerates during sleep"
| Dates: | 4 March 2024 |
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| Times: | 15:00 - 16:00 |
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| What is it: | Seminar |
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| Organiser: | Faculty of Biology, Medicine and Health |
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Division of Cancer Services (DCS) Next-Generation seminar
Speaker: Dr Zoi Diamantopoulou, Junior Group Leader, CRUK Beatson Institute / University of Glasgow
Title: The metastatic spread of breast cancer accelerates during sleep
When: Monday 4th March 2024
Time: 3pm - 4pm
Venue: OCRB Lecture Theatre, 555 Wilmslow Rd, Manchester M20 4GJ
Host: Hannah Harrison
Metastasis is the leading cause of all cancer relate deaths. CTCs (Circulating Tumour Cells) – cancer cells that escape from tumours and navigate the bloodstream on their way to distant organs – are pioneers of metastasis. But when do CTCs emerge, and when does metastasis take root? Previous studies have shown that metastasis is an early event in cancer progression. However, the temporal dynamics governing the generation of metastasis-competent CTCs were, until recently, largely uncharacterized and there was often the assumption that CTCs are constantly shed from growing tumours. Here, I will present data revealing a striking and unexpected pattern of CTC generation dynamics in both patients with breast cancer and mouse models, highlighting that most spontaneous CTC intravasation events occur during sleep. I will show that rest-phase CTCs are highly prone to metastasize, whereas CTCs generated during the active phase are devoid of metastatic ability. Furthermore, I will delve into the mechanisms regulating the temporal dynamics of metastasis. Finally, I will discuss how these finding could be translated into clinical applications and pave the way for the development of novel, time-tailored approaches for the treatment of metastasis-prone cancers.
If you would like a 1 –2- 1 with Zoi during the day, or to join the PhD student/Post-doc lunch meeting, please contact rebecca.murray@manchester.ac.uk
Travel and Contact Information
Find event
Oglesby Cancer Research Building (OCRB)
555 Wilmslow Rd
Manchester
