BEGIN:VCALENDAR
PRODID:-//Columba Systems Ltd//NONSGML CPNG/SpringViewer/ICal Output/3.3-
 M3//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20160310T111256Z
DTSTART:20160315T130000Z
DTEND:20160315T140000Z
SUMMARY:Plasticity in Differentiation – How do Cells Stahl for Time in th
 e Decision Making Process?
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}q6e-ieztgvn
 8-4ojh1g
DESCRIPTION:Embryonic stem cells (ESCs) are immortal cell lines derived f
 rom the peri-implantation mammalian embryo.  Both ESCs and the embryos f
 rom which they are derived are remarkable\, in that individual cells ret
 rain the capacity to begin developmental anew\, despite having undergone
  a degree of patterning or differentiation.  What is the basis for this 
 plasticity at a transcriptional level?  We have identified two new mecha
 nisms regulating this process.  The first involves a protective activity
  of Polycomb co-repressor complexes\, that enables transcriptional up re
 gulation in the absence of commitment.  The second relies on the reversi
 ble disengagement of RNA PolII from specific promoters in response to si
 gnalling.  I will discuss these mechanisms and how they impact on the ca
 pacity of ESCs to retain their plasticity in self renewal. 
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:Michael Smith Lecture Theatre\, Michael Smith Building\, Manches
 ter
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