J. Patrick Pett -- Generation of mammalian circadian rhythms by a network of multiple feedback loops
|Dates:||16 June 2021|
|Times:||13:00 - 14:00|
|What is it:||Seminar|
|Organiser:||Department of Mathematics|
|Who is it for:||University staff, External researchers, Current University students|
|Speaker:||J. Patric Pett|
Join us for this seminar by J. Patrick Pett (Sanger) as part of the North West Seminar Series in Mathematical Biology and Data Sciences. Details of the full series can be found here https://www.cms.livjm.ac.uk/APMSeminar/
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Abstract: Daily changes in the environment are anticipated by many organisms with the help of circadian clocks which allow them to adapt their physiology and behaviour accordingly. In mammals, these clocks are based on a network of gene transcriptional-translational feedback loops (TTFL) present in almost every cell. Circadian clocks in different organs are distinguished based on the functions that are regulated in a daily manner and varying routes of coupling and entrainment.
Using a mathematical model we found that multiple feedback loops can generate circadian rhythms, including a newly described gene combination that forms a repressilator motif. Fitting the generic multi-feedback model to tissue-specific data we also find that different combinations of loops can generate rhythms synergistically depending on the tissue. Such a network of feedbacks can provide the flexibility to create circadian oscillations with various phase patterns and amplitudes of individual genes. A tissue-dependent use of feedbacks in the model might be related to the different functions and dominant entrainment signals for organs.
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J. Patric Pett
Role: Postdoctoral Researcher
Organisation: Wellcome Sanger Institute
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