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CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20141212T102504Z
DTSTART:20150121T123000Z
DTEND:20150121T140000Z
SUMMARY:MHS Faculty Research Series |  Professor Garth Cooper and Dr Kath
 arine Dibb
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DESCRIPTION:'''Host:''' Institute of Human Development and Institute of C
 ardiovascular Sciences\n\n'''Speakers:''' \n\nSenior presenter: \n\nProf
 essor Garth Cooper\, Professor of Discovery and Experimental Therapeutic
 s\, Centre for Advanced Discovery and Experimental Therapeutics\, Instit
 ute of Human Development: \n\nTitle: “Regeneration of the heart in diabe
 tes”\n\nThe aim of my research programme\, since its inception in the ea
 rly 1980s\, is to develop rigorous molecular explanations for the aetiop
 athogenesis of ageing-related diseases such as diabetes mellitus and the
  metabolic syndrome\, where there is agreed\, major unmet clinical need.
    My work has two linked objectives: The first is to describe the molec
 ular basis of pathogenetic processes\, through quantitative analysis of 
 the phenotypes of human diseases and relevant non-clinical models (the m
 odels must meaningfully replicate human pathogenetic disease processes).
  I aim to understand modifications in tissue composition through measure
 ments of proteins\, carbohydrates\, lipids\, metals and gene transcripts
 \, and thereby to understand the pathogenetic processes causing these ch
 anges. This work aims to generate new/improved methods of diagnosis\, an
 d for therapeutic monitoring.  The second is to develop new experimental
  therapeutic molecules for intervention in the pathogenetic processes un
 der study\, thereby to confirm/refute hypotheses concerning their molecu
 lar basis. This route leads to new first-in-class medicines.\n\nJunior p
 resenter:\n\nDr Katharine Dibb\, Lecturer\, Institute of Cardiovascular 
 Sciences: \n\nTitle: “Alterations to atrial structure and function in he
 art failure: can dysfunction be reversed?”\n\nMy research is focused on 
 the atria of the heart and how it functions in health and disease. Despi
 te the prevalence of atrial diseases such as atrial fibrillation\, far l
 ess is known about the atria compared to the well-studied ventricle and 
 we are addressing this from two angles. Firstly we have identified struc
 tures in the atria that are not only important for normal contraction bu
 t whose loss in heart failure contributes to dysfunction. Current work i
 s focused on the restoration of these structures with the overall aim be
 ing to improve function of the diseased heart via novel therapeutic targ
 ets. Our second objective is to understand how atrial structure and func
 tion is remodelled during normal ageing. This work has identified mechan
 isms which could increase susceptibility of the aged atria to disease. \
 n\n'''About the research series:'''\n\nThe monthly Faculty Research Seri
 es events are open to all staff and students from across the Faculty of 
 Medical and Human Sciences and the University\, offering an opportunity 
 to celebrate research achievement and stimulate scientific interaction. 
 Each month one host School or Institute from the Faculty will pair with 
 a different School or Institute to highlight and showcase similar topics
  from different perspectives. The 2014 series is led by Professor David 
 Eisner and administered from the Faculty Research Office.\n\n'''Schedule
 :'''\n\nHeld on Wednesday lunchtimes\, each meeting lasts an hour\, incl
 uding two 20-25 minute presentations – one from a junior and one from a 
 more senior member of Faculty staff. Each presentation will be followed 
 by a short discussion. A buffet lunch will be available from 12.30. Pres
 entations begin at 1pm.\n\n'''Registration:'''\n\nPlease note that place
 s will be limited so registration is essential\, please register via [ht
 tp://mhsfrs21jan2015.eventbrite.co.uk Eventbrite]\n\n\n
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:Michael Smith Lecture Theatre\, Michael Smith Building\, Manches
 ter
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