Events at The University of Manchester
  • University home
  • Events
  • Home
  • Exhibitions
  • Conferences
  • Lectures and seminars
  • Performances
  • Events for prospective students
  • Sustainability events
  • Family events
  • All Events

Special seminar: Glypicans shield the lipid moiety of Wnts to enable signalling at a distance

Dates:9 March 2020
Times:11:00 - 12:00
What is it:Seminar
Organiser:Faculty of Biology, Medicine and Health
Who is it for:University staff, Current University students
Speaker:Ian McGough
See travel and contact information
Add to your calendar

Other events

  • In category "Seminar"
  • By Faculty of Biology, Medicine and Health

Abstract: A relatively small number of proteins have been suggested to act as morphogens, signalling molecules that spread within tissues to organize cell fate specification during development and tissue repair. Among them are Wnt proteins, which carry a palmitoleate moiety that is essential for signalling activity. How can a hydrophobic lipoprotein spread in the aqueous extracellular space? I will provide evidence that the Wnt lipid is shielded by the core domain of a subclass of glypicans defined by the Dally-like protein (Dlp). Structural analysis shows that, in the presence of palmitoleated peptides, these glypicans change conformation to create a hydrophobic space. Thus, glypicans of the Dlp family protect the lipid of Wnts from the aqueous environment and serve as a reservoir from where Wnts can be handed over to signalling receptors.

Speaker

Ian McGough

Organisation: Francis Crick Institute

Travel and Contact Information

Find event

B.4208
Michael Smith Building
Manchester

 

Contact us

  • +44 (0) 161 306 6000

Find us

The University of Manchester
Oxford Rd
Manchester
M13 9PL
UK

Connect with the University

  • Facebook page for The University of Manchester
  • X (formerly Twitter) page for The University of Manchester
  • YouTube page for The University of Manchester
  • Instagram page for The University of Manchester
  • TikTok page for The University of Manchester
  • LinkedIn page for The University of Manchester

  • Privacy /
  • Copyright notice /
  • Accessibility /
  • Freedom of information /
  • Charitable status /
  • Royal Charter Number: RC000797
  • Close menu
  • Home
    • Featured events
    • Today's events
    • The Whitworth events
    • Manchester Museum events
    • Jodrell Bank Discovery Centre events
    • Martin Harris Centre events
    • The John Rylands Library events
    • Exhibitions
    • Conferences
    • Lectures and seminars
    • Performances
    • Events for prospective students
    • Sustainability events
    • Family events
    • All events