Seminar - Modelling Expression Rates of Hypoxia-inducible Factors in Growing Tumours: Investigating Potentials for Non-Invasive Cancer Therapies
| Dates: | 9 October 2019 |
|---|
| Times: | 14:00 - 14:30 |
|---|
| What is it: | Seminar |
|---|
| Organiser: | Department of Computer Science |
|---|
| Who is it for: | University staff, Adults, Current University students |
|---|
| Speaker: | Dario Panada |
|---|
|
Join us for the first PG Computer Science Mercury Seminar with speaker Dario Panada
In-silico modelling has the potential to complement laboratory studies by accurately simulating biological processes, offering insights into tumour dynamics, significantly reducing experimental costs, and improving the quality of measurements. Furthermore, in-silico studies allow to explore counterfactual situations and test multiple hypotheses in a quick and efficient manner. We have developed a comprehensive artificial model (informed by the medical literature) to investigate the potential for a novel non-invasive therapy aimed at containing cancer growth in tumour cells. Hypoxia-Inducible Factors have been previously identified as a target for non-invasive cancer therapy, where the requirement being that their expression could be artificially enhanced. While anti-angiogenic therapy has been suggested as potential vehicle to achieve this, the extent to which it is possible remains unclear, due to the challenges of making the necessary in-vivo measurements. We executed in-silico experiments to explore the effects of anti-angiogenic therapy. The results suggest that it can successfully act as a necessary precursor predisposing the tumour mass to non-invasive anti-cancer therapies. In addition to the medical value of the results, the results also highlight the importance of in-silico approaches as a complement to laboratory studies. The present study paves the way for future in-silico and laboratory experiments aiming at devising non-invasive therapies based on the joint action of anti-angiogenic and hypoxia-inducible-factor targeting.
Speaker
Dario Panada
Role: PGR student
Organisation: University of Manchester
Travel and Contact Information
Find event
Kilburn Lecture Theatre 1.5
Kilburn Building
Manchester
