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Ed Morrisey - Studying the fixation and spread of mutations in human epithelium by combining modelling and deep learning

Patterned pufferfish scales demonstrating a Turing pattern in the natural world
Dates:12 October 2020
Times:14:00 - 15:00
What is it:Seminar
Organiser:Department of Mathematics
Who is it for:University staff, External researchers, Current University students
Speaker:Edward Morrisey
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  • Mathematics in the life sciences
  • Department of Mathematics

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  • In category "Seminar"
  • In group "(Maths) Mathematics in the life sciences "
  • In group "(Maths) Maths seminar series"
  • By Department of Mathematics

(via Zoom) Join us for this seminar by Ed Morrisey (Oxford) as part of the North West Seminar Series in Mathematical Biology and Data Sciences. Details of the full series can be found here https://www.cms.livjm.ac.uk/APMSeminar/

Abstract: Most adult tissues are stem cell fuelled. Not only do these stem cells provide new cells to the tissue, they also slowly replace each other leading to a form of competition. It is currently thought that it is during this replacement process that mutations can spread and, in some cases, eventually lead to cancer. I will describe how combining Deep Learning for tissue analysis with stochastic modelling of stem cell dynamics we can study how mutations are seeded in human epithelium, how they spread and whether particular mutations make the stem cells more fit.

Details of the zoom meeting ID and link will be sent via the Maths in the Life Sciences mailing list. If you have missed the e-mail please contact the seminar organiser directly (carl.whitfield@manchester.ac.uk).

To subscribe to the mailing list for this event series, please send an e-mail with the phrase “subscribe math-lifesci-seminar” in the message body to listserv@listserv.manchester.ac.uk

Speaker

Edward Morrisey

Role: MRC WIMM Group Leader

Organisation: University of Oxford

  • https://www.rdm.ox.ac.uk/people/edward-morrissey

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Carl Whitfield

carl.whitfield@manchester.ac.uk

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