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METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20250117T131318Z
DTSTART:20250205T140000Z
DTEND:20250205T150000Z
SUMMARY:Manchester Neuroscience Seminar Series - Speaker: Dr Ximena Soto 
 rodriguez from the University of Manchester
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}r1f3-m60s5o
 nz-cul2e7
DESCRIPTION:Please join us for the Manchester Neuroscience Seminar Series
 \, Wednesday 5 February 2025 14:00 – 15:00\, the speaker is Dr Ximena So
 to rodriguez from the University of Manchester.\n\nThe host will be Dr N
 ina Milosavljevic\n\nTitle: "The role of dynamic expression in neurogene
 sis during development and regeneration"\n\nAbstract: The development of
  the brain requires a tight balance between stem cell proliferation and 
 differentiation. Previous work has shown that specific genes\, such as t
 he Her/Hes transcription repressor family\, are essential for the mainte
 nance of neuronal stem cells and factors such as the microRNA (miR)\, co
 ntrols their expression. My own research has shown that during developme
 nt the generation of new neurons\, genes (i.e. Her/Hes gene family) are 
 not simply on or off. Instead\, their levels pulse dynamically over time
 \, influenced by the miR\, and control whether the cells stay as prolife
 rating progenitors or becoming new neurons. \n\nIt is known that the sam
 e genes involved in development of the nervous system are reactivated up
 on spinal cord (SC) injury and are important during SC regeneration. How
 ever\, the mechanisms are unknown. Therefore\, it is not clear whether d
 uring SC regeneration and the generation of new neurons are also control
 led by the pulses in gene expression. \n\nIn this presentation I describ
 e using the zebrafish model to study dynamic gene expression during deve
 lopment of the nervous system and then go on to discuss ongoing work on 
 its role in SC regeneration. This work focus studying Her dynamic expres
 sion and how miR finely-tune its expression providing an understanding o
 n the mechanism and functional importance of pulsatile gene activity dur
 ing neuronal cell-fate decisions in development and regeneration. This w
 ill grant new insights with potential translational implications for inj
 uries on SC in animals with no regenerative capacity\, such as mice and 
 humans.\n\n\nWhere: The seminar will take place in the Michael Smith Lec
 ture Theatre\n\n
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:Michael Smith Lecture Theatre\, Michael Smith Building\, Manches
 ter
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