Carina Dunlop -- What do cells and tissues feel? The integration of cellular contractility, extracellular adhesion and tissue stiffness in mechanosensing.[IN PERSON]
|Starts:||14:00 12 Dec 2022|
|Ends:||15:00 12 Dec 2022|
|What is it:||Seminar|
|Organiser:||Department of Mathematics|
|Who is it for:||University staff, External researchers, Current University students|
Join us for this seminar by Carina Dunlop (Surrey) as part of the North West Seminar Series in Mathematical Biology and Data Sciences. Details of the full series can be found here https://www.cms.livjm.ac.uk/APMSeminar/
The talk will be hosted in person in the Simon Building, Room 4.38. For those who cannot attend in person the talk will also be streamed via zoom, please contact firstname.lastname@example.org or email@example.com for the zoom link, or sign up to the mailing list.
Abstract: The role of tissue stiffness in controlling cell behaviours is well established. This has been shown across cell types and includes behaviours such as cell differentiation and even drug susceptibility, with clear implications for health and disease. In experimental investigation of mechanosensation the use of bioengineered gels with defined mechanical properties have become essential to mimic varying tissue microenvironments. However, I show here that the stiffness experienced by the cell is not only determined by the actual stiffness but rather incorporates the interplay between contractility, cell adhesion and mechanical response. I will also discuss how these observations scale up in whole tissues looking at recent experimental observations in epithelial sheets, and at the role geometrical constraints play in three-dimensional tissues.
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Role: Senior Lecturer
Organisation: University of Surrey
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