Who put the phase delay in? And why size matters. Looking at connectivity during the development and growth of the Drosophila motor network.
|Starts:||15:30 12 Apr 2016|
|Ends:||17:00 12 Apr 2016|
|What is it:||Seminar|
|Organiser:||Faculty of Life Sciences|
|Who is it for:||University staff|
We are trying to understand how those parts of the nervous system develop that generate behaviour. Working with the fruitfly, Drosophila melanogaster, allows us to tap into a rich repertoire of genetic tools with which to visualise and manipulate identified nerve cells. We have studied the organisation of the larval locomotor circuitry, and recently discovered the neurons that regulate sequential muscle contractions during larval crawling. We showed that the highly branched dendrites are important to balancing connections between neurons. As animals grow, hormonal signals trigger neuronal growth, and through this connectedness and activity levels. Over-activation, on the other hand, is detected through metabolic reactive oxygen species, which instruct homeostatic reductions in synaptic terminal size.
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