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METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20250408T040115Z
DTSTART:20250428T110000Z
DTEND:20250428T120000Z
SUMMARY:Advances in Biosciences Seminar Series - Professor Janni Petersen
 \, Professor in Cancer Cell Biology\, Flinders University\, Australia
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}s215-m976a1
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DESCRIPTION:Join the Division of Molecular and Cellular Function (MCF) fo
 r the Advances in Biosciences Seminar Series\, the speaker will be Profe
 ssor Janni Petersen\, Professor in Cancer Cell Biology from Flinders Uni
 versity\, Australia\n\nThe seminar will be hosted by Dr Lisa Swanton.\n\
 nTitle: "Targeting Cell Signalling in Nutrient-Stressed Environments for
  Cancer Therapy"\n\nAbstract: Using the single-celled organism yeast and
  cancer-derived tissue cultures\, we characterize nutrient-dependent cel
 l signalling\, focusing primarily on the Target of Rapamycin (TOR) and A
 MP-dependent protein kinase (AMPK) signalling pathways. We employ time-r
 esolved mass spectrometry and a drug-induced strategy to manipulate TOR 
 Complex 1 (TORC1) and AMPK activity in yeast. This approach has identifi
 ed numerous conserved novel phosphorylation sites in essential regulator
 s of nutrient sensing\, cell proliferation\, and long-term survival unde
 r nutrient stress.\nWe have translated several of our findings from yeas
 t to human cell lines to identify nutrient-dependent cell signalling pat
 hways crucial for cancer cell proliferation and survival. Our goal is to
  leverage the unique characteristics of cancer cells regarding their nut
 ritional status. Gaining this insight could pave the way for developing 
 targeted drugs that exploit the vulnerabilities of cancer cells without 
 affecting the rest of the patient\, thereby reducing the adverse side ef
 fects associated with chemotherapy.\n
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:Michael Smith Lecture Theatre\, Michael Smith Building\, Manches
 ter
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