BEGIN:VCALENDAR
PRODID:-//Columba Systems Ltd//NONSGML CPNG/SpringViewer/ICal Output/3.3-
 M3//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20150612T113509Z
DTSTART:20150623T120000Z
DTEND:20150623T130000Z
SUMMARY:Noradrenaline mediates the bidirectional modulation of motor cort
 ex output during motor behaviour
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}s8w-iatjdmj
 4-58bvtr
DESCRIPTION:This seminar is part of the Future Leaders Series\, showcasin
 g the best early-career researchers working the fields of sensory and co
 mputational neuroscience.                                               
                                                                         
                                                                         
                                                                         
                                                                         
                                                                         
                                                                   Abstra
 ct:                                                                     
                                                                         
                                                                         
                     Neuronal activity in primary motor cortex (M1) corre
 lates with behavioural state\, but the cellular mechanisms underpinning 
 behavioural state-dependent modulation of M1 output remain largely unres
 olved. Here we performed in vivo patch-clamp recordings from layer 5B (L
 5B) pyramidal neurons in awake mice during quiet wakefulness and self-pa
 ced\, voluntary movement. We show that L5B output neurons display bidire
 ctional (i.e. enhanced or suppressed) firing rate changes during movemen
 t\, mediated via two opposing subthreshold mechanisms: 1) a global decre
 ase in membrane potential variability that reduced L5B firing rates (L5B
 suppressed neurons)\; and 2) a coincident noradrenaline-mediated increas
 e in excitatory drive to a subpopulation of L5B neurons (L5Benhanced neu
 rons) that elevated firing rates. Blocking noradrenergic receptors in fo
 relimb M1 abolished the bidirectional modulation of M1 output during mov
 ement and selectively impaired contralateral forelimb motor coordination
 . Together\, our results provide a mechanism for how noradrenergic neuro
 modulation and network-driven input changes bidirectionally modulate M1 
 output during motor behaviour.\n\nHost: Mark Humphries
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:4.005\, AV Hill Building\, Manchester
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