Control of mesenchymal stem cell growth and phenotype using nanoscale materials approaches
|20 May 2016
|14:00 - 15:00
|What is it:
|Faculty of Life Sciences
|Who is it for:
|University staff, Current University students
|Professor Matthew Dalby
Part of the Manchester Tissue Regeneration & Stem Cell Network Seminar Series.
How mesenchymal stem cell fate is controlled by the cell/material interface is becoming better understood in terms of material chemistry, mechanical properties and topography. We have focused on the use of nanoscale topography to target MSC differentiation to bone with a view to design of new orthopaedic materials. However, we have also studied MSC growth without differentiation using nanotopography. This is important if we wish to expand large numbers of high quality autologous MSCs for clinical use. We have shown that control of adhesion and cytoskeletal tension is important in regulating growth through mitogen activated protein kinases and subtle alterations in cell cycle. From these observation we have gone on to develop dynamic growth platforms that allow first MSC expansion and then targeted differentiation on user demand and also to start to bioengineer 3D bioengineered MSC niches that could be useful in e.g. drug testing. These observations and concepts will be explored during this talk.
Professor Matthew Dalby
Organisation: University of Glasgow
Travel and Contact Information
Michael Smith Lecture Theatre
Michael Smith Building