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PRODID:-//Columba Systems Ltd//NONSGML CPNG/SpringViewer/ICal Output/3.3-
 M3//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20140227T104037Z
DTSTART:20140306T090000Z
DTEND:20140306T100000Z
SUMMARY:Ion mobility mass spectrometry - measuring more than mass
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}tow-hs5w8sj
 j-hvkjeh
DESCRIPTION:A Gene Regulation and Biotechnology Seminar\n                
                                                                         
                                                                         
                                                                         
                                                                         
                                                                         
                                                                         
                                                                         
                                                                         
                                                                         
                                                                         
                                                                         
                                                                         
           The analytical advantages of mass spectrometry apply to its us
 e to examine intact proteins and complexes and there is an emerging rese
 arch field that identifies proteins this way – so called “top-down” meth
 odologies where proteins are sequenced in their entirety in the mass spe
 ctrometer. Most top down approaches destroy the functional form of the p
 rotein prior to sequencing\, to enable higher throughput and to facilita
 te more productive analysis from higher charged parent ions. This is not
  the route we take\, rather we aim to probe intact proteins and complexe
 s \, with careful use of nano-electrospray ionisation (nESI) to retain s
 olution structures. Native mass spectrometry provides information about 
 tertiary and quaternary structure\, and intramolecular interactions. Thi
 s talk will discuss recent results from our lab with an emphasis on unde
 rstanding protein structure and dynamics.
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:1.006\, AV Hill Building\, Manchester
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