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METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20250219T101924Z
DTSTART:20250303T140000Z
DTEND:20250303T150000Z
SUMMARY:Prof Nir Gov -- Modelling the migration of branched cells on netw
 orks [IN PERSON]
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}u1c5-m5p5tu
 e2-plg5n0
DESCRIPTION:Join us for this seminar by Prof Nir Gov (Weizmann Institute\
 , Israel) as part of the North West Seminar Series in Mathematical Biolo
 gy and Data Sciences. More details about the joint series can be found h
 ere https://northwestseminars.great-site.net/ . \n\nThe talk will be hos
 ted in person in room 2.61 of the Simon Building. For those who cannot a
 ttend in person the talk will also be streamed via zoom\, please contact
  carl.whitfield@manchester.ac.uk or igor.chernyavsky@manchester.ac.uk fo
 r the zoom link\, or sign up to the mailing list.\n\nTitle: "Modelling t
 he migration of branched cells on networks"\n\nAbstract: Migrating cells
  often face microenvironmental constraints that force them to extend mul
 tiple\, often highly dynamic\, protrusions\, that compete to choose the 
 new direction of motion. This is observed during the migration of immune
  and cancer cells inside living tissues. However\, of how cells coordina
 te shape dynamics during this directional decision-making (DDM) process 
 is not yet fully understood. We present a coarse-grained theoretical mod
 el that allows us to explore the shape dynamics of migrating cells as th
 ey perform DDM. We start with cells moving on a single Y-junction\, and 
 find that the model predicts deterministic see-saw oscillations between 
 the cellular arms during DDM. This prediction is verified by experiments
  on sevreal cell types. We next explore the shape dynamics of highly bra
 nched cells\, and find that cells become less persistent when more branc
 hed. This prediction suggests a tradeoff between sensitivity and robustn
 ess during migration on complex geomtries\, and we compare to observatio
 ns of cells migrating on patterned substrates. We end by showing the che
 motaxis properties of branched-cells\, with consequences for immune cell
 s swarming to a wound\, as observed for neutrophiles in in-vivo experime
 nts.\n\nTo subscribe to the mailing list for this event series\, please 
 send an e-mail with the phrase “subscribe math-lifesci-seminar” in the m
 essage body to listserv@listserv.manchester.ac.uk
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:2.61\, Simon Building\, Manchester
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