Oscillating signaling pathways during mouse embryo development and scaling
| Dates: | 13 May 2014 |
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| Times: | 13:00 - 14:00 |
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| What is it: | Seminar |
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| Organiser: | Faculty of Life Sciences |
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| Who is it for: | University staff, Current University students |
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| Speaker: | Alexander Aulehla |
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This seminar is part of the Tissue Systems seminar series. Abstract: In our group, we are focusing on the temporal aspect of embryonic development and thus on the role of embryonic clocks, or oscillators. Oscillations in Wnt, Fgf and Notch-signaling pathway activity (period ~2hours) have been identified during mesoderm patterning in vertebrate embryos and are linked to the formation of pre-vertebrae, or somites. Most strikingly, oscillations occur phase-shifted between neighbouring cells, producing spatio-temporal activity patterns within the embryo. Using a combination of genetically engineered dynamic reporter mouse lines, functional perturbations and quantitative in vivo measurements, we address the role of these signaling oscillations during mesoderm patterning and scaling.
Speaker
Alexander Aulehla
Organisation: EMBL Heidelberg
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Lecture Theatre
Michael Smith Building
Manchester
