BEGIN:VCALENDAR
PRODID:-//Columba Systems Ltd//NONSGML CPNG/SpringViewer/ICal Output/3.3-
 M3//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20200123T090831Z
DTSTART:20200131T113000Z
DTEND:20200131T123000Z
SUMMARY:MaRMN Special Seminar: Mekayla Storer\, Hospital for Sick Childre
 n\, Toronto
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}vbe-k5pi76k
 j-xnf1dm
DESCRIPTION:Mekayla A. Storer\,  Program in Neurosciences and Mental Heal
 th\, Hospital for Sick Children\, Toronto\, Canada \n\n\nAbstract: \nReg
 eneration of appendages is relatively common among invertebrates. In mam
 mals\, however\, multi-tissue regeneration is largely restricted to the 
 distal portion of the digit tip\, and involves the formation of a blaste
 ma\, a heterogeneous\, transiently proliferating cell mass that forms be
 tween the injured bone and the newly formed epidermis. \n\nWhile the bla
 stema is becoming increasingly well understood in amphibians\, in mammal
 s\, we do not know where most mesenchymal blastema cells come from\, wha
 t cellular state they adopt as blastema cells and/or whether they are fl
 exible in terms of the mesenchymal lineages they generate. Here\, we sho
 w that Pdgfra-expressing mesenchymal cells in uninjured adult murine dig
 its establish the regenerative blastema and are essential for successful
  regeneration. \n\nSingle cell profiling demonstrates that the mesenchym
 al blastema cells are distinct from both uninjured digit and embryonic l
 imb/digit Pdgfra-positive cells. This unique state is environmentally de
 termined\, since dermal fibroblasts transplanted into the regenerating d
 igit will acquire a blastema phenotype and contribute to bone regenerati
 on. Similarly\, lineage tracing and single cell profiling show that endo
 genous bone-associated mesenchymal cells also acquire the blastema trans
 criptional identity and contribute to dermis and bone regeneration. \n\n
 Thus\, mammalian digit tip regeneration occurs via a distinct adult mech
 anism where the regenerative environment promotes acquisition of a uniqu
 e blastema state that allows cells to contribute broadly to mesenchymal 
 tissue repair and regeneration. Therefore\, if we can understand the gro
 wth factors and signalling cascades that regulate blastema formation and
  cellular plasticity\, this might tell us why regeneration fails in most
  mammalian situations and provide insights into therapeutic strategies f
 or reversing this failure.  \nFriday 
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:Michael Smith lecture theatre\, Michael Smith Building\, Manches
 ter
END:VEVENT
END:VCALENDAR