Neuroscience Seminar

Dates:	19 September 2019
Times:	12:00 - 13:00
What is it:	Seminar
Organiser:	Faculty of Biology, Medicine and Health
Who is it for:	University staff
Speaker:	Professor Johannes Boltze

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Stroke modelling in sheep: methods, applications and contributions to translational research

Professor Johannes Boltze School of Life Sciences, The University of Warwick

Synopsis: Although indispensable for basic research, rodent stroke models offer limited comparability with human stroke. This is believed to hamper the transfer of promising novel therapeutic and diagnostic procedures for stroke from the lab to the clinics. Large animal models could fill this translational gap, verifying the impact of such procedures in a gyrencephalic brain and in an experimental setup closer to human stroke care. While being laborious to employ, large animal models offer a number of additional advantages such as compatibility with clinical imaging technology. The talk will briefly review existing large animal stroke models and will provide details on stroke modelling in sheep. It will also provide examples on how the model has been used in translational stroke research spanning from a cell therapeutic approach, over an innovative approach to preserve the penumbra to a direct comparison between PET and MRI-based penumbra assessment in humans and sheep.

Biography: 2019-present Professor of Neuroscience, University of Warwick, UK 2015-18 Full Professor of Cell Technology and Head, Department of Cell Technology and Translational Medicine, Fraunhofer EMBT, Luebeck, Germany 2009-15 Head, Department of Cell Therapy, Fraunhofer IZI, Leipzig, Germany 2006-09 Head, Neurorepair Research Group, Fraunhofer IZI, Leipzig, Germany 2012 PhD (Dr. rer. nat.) University of Leipzig 2008 MD (Dr. med.) University of Leipzig

Dr. Boltze has published 115 peer-reviewed papers, 6 peer-reviewed book chapters and holds 6 patents. He is also the president of the biannual International Symposium on Neuroprotection & Neurorepair (ISN&N). https://warwick.ac.uk/fac/sci/lifesci/people/jboltze/

Speaker

Professor Johannes Boltze

Organisation: The University of Warwick

Biography: Dr. Boltze has published 115 peer-reviewed papers, 6 peer-reviewed book chapters and holds 6 patents. He is also the president of the biannual International Symposium on Neuroprotection & Neurorepair (ISN&N).