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PRODID:-//Columba Systems Ltd//NONSGML CPNG/SpringViewer/ICal Output/3.3-
 M3//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20150514T080511Z
DTSTART:20150519T100000Z
DTEND:20150519T110000Z
SUMMARY:Phosphate uptake in yeast in an alkaline environment: problems an
 d solutions
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}w1x-i9mv17z
 q-lxsbcs
DESCRIPTION:Special Seminar\n\nThe yeast Saccharomyces cerevisiae has an 
 undeniable importance in biotechnological applications and it is also an
  important model for research in molecular biology. This yeast prolifera
 tes preferably in an acidic environment and\, in many cases\, uptake of 
 nutrients is based in a co-transport with H+. Therefore\, even a modest 
 alkalisation of the medium has a major impact on this organism\, which r
 eacts with a robust adaptive response that involves an extensive remodel
 ling of the gene expression pattern. The signalling pathways that are in
 volved in this transcriptional response are multiple\, forming a network
  of regulatory interactions that has been revealed in recent years (1). 
 Furthermore\, certain genes may integrate regulatory inputs from various
  pathways\, thereby allowing fine-tuning of the response. An interesting
  example is the uptake of phosphate (Pi) under alkaline conditions. Unde
 r these conditions the usual transport\, based on a H+ / Pi co-transport
 \, becomes less effective and the yeast has to launch an unusual mechani
 sm based in a Na+ / Pi co-transporter\, encoded by the PHO89 gene. Altho
 ugh efficient enough\, this method involves an associated problem: the u
 ptake of Na+ cations\, which are toxic. Our investigations (2\, 3) have 
 revealed a common signalling network that controls the expression of PHO
 89 and that of the Na+-ATPase ENA1 in response to alkalinisation of the 
 environment. Functional coupling of both proteins allows yeast maintain 
 phosphate uptake without being exposed to deleterious side effects. \n \
 n1. J. Arino\, OMICS. 14\, 517 (2010). \n2. M. Platara et al.\, J. Biol.
  Chem. 281\, 36632 (2006). \n3. A. Serra-Cardona\, S. Petrezselyova\, D.
  Canadell\, J. Ramos\, J. Arino\, Mol. Cell Biol 34\, 4420 (2014).\n\nHo
 sted by Dr Lydia Tabernero and Dr Mike Bromley\n\nIf you would like to m
 eet with Professor Joaquin Arino\, please contact Dr Lydia Tabernero (ex
 t. 57794)
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:1.006\, AV Hill Building\, Manchester
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