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METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20140219T100040Z
DTSTART:20140219T130000Z
DTEND:20140219T140000Z
SUMMARY:Modelling beta band oscillations in the Subthalamic Nucleus - Glo
 bus Pallidus network
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}wlj-hrt5bhm
 u-3t2oub
DESCRIPTION:This seminar is part of the Neurophysiology Seminar series   
      \n\nNeuronal firing in the basal ganglia - cortex network shows a n
 umber of characteristic peaks in its frequency spectrum\, most prominent
 ly one at beta (20-30Hz) and another at gamma (60-90Hz) bands. While gam
 ma band tends to correlate with the execution of voluntary movement\, be
 ta band correlates with the blockade of motor activity or the maintenanc
 e of static postures. Additionally\, Parkinson's disease (which is chara
 cterised by the inability to execute voluntary movements) is accompanied
  by exacerbated beta band activity in this network. Due to these strikin
 g correlations\, it is of central importance to elucidate the functional
  relationship between beta oscillations and motor control. Here\, we pre
 sent one of the basal ganglia models that aim at addressing this questio
 n. In this case\, the model reproduces the firing rates observed in the 
 subthalamic nucleus - globus pallidus circuit\, a basal ganglia sub-netw
 ork whose architecture is prone to oscillatory activity. Analysis of the
  model suggests a central role of this sub-network in the exacerbation o
 f beta band in Parkinson disease. Additionally\, modelling also suggests
  the existence of two very different channels travelling through the glo
 bus pallidus\, a feature which very probably have crucial implications i
 n the processing of motor information through the basal ganglia - cortex
  network.\n\n
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:4.005\, AV Hill Building\, Manchester
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