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BEGIN:VEVENT
DTSTAMP:20240830T132620Z
DTSTART:20241001T120000Z
DTEND:20241001T130000Z
SUMMARY:Advances in Biosciences Seminar Series- Professor Sirio Dupont fr
 om the University of Padova\, Italy. Title: Mechanobiology and metabolis
 m in cancer
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 5-hjadnl
DESCRIPTION:Introducing the first speaker in October for the Advances in 
 Biosciences Seminar Series\; Professor Sirio Dupont from the University 
 of Padova\, Italy.\n\nTitle: Mitochondrial mechanotransduction: a unifyi
 ng pathway in the cellular response to forces?\n\nAbstract: Is cell meta
 bolism coordinated with tissue architecture and cell shape? In the last 
 years my lab explored this question trying to identify and understand th
 e molecular mechanisms by which forces and the mechanical properties of 
 the microenvironment instruct cell behavior. In this context we discover
 ed a novel function of mitochondria as signaling hubs coordinating the t
 ranscriptional and metabolic response to forces. ECM stiffness\, spatial
  confinements\, and applied forces including stretching of the mouse ski
 n regulate mitochondrial dynamics. Forces do so by promoting phosphoryla
 tion of a mitochondrial outer membrane protein\, limiting the recruitmen
 t of DRP1 at mitochondria and ultimately reducing mitochondrial fission.
  In turn\, mitochondrial fission is also a general mechanotransduction m
 echanism. Indeed\, we found that mechano-dependent fission is required a
 nd sufficient to regulate three transcription factors of broad physiolog
 ical and pathological relevance to control cell proliferation\, lipogene
 sis\, antioxidant metabolism\, chemotherapy resistance\, and adipocyte d
 ifferentiation in response to mechanical cues. This extends to the mouse
  liver\, where DRP1 regulates hepatocyte proliferation and identity. We 
 propose that mitochondria fulfill a unifying signaling function by which
  complementary cell functions are coordinated and harmonized with the me
 chanical tissue microenvironment.\n\nSpeaker Bio: Black sheep in a famil
 y of artists and humanists\, I chose to study science and took a Biology
  degree\, in Padua. Mad about molecular and developmental biology\, I th
 rew myself headlong into a PhD\, in Padua. The family grows\, results ar
 e good\, passion remains burning\, I try my chance with Academia and I b
 ecome Assistant Professor\, in Padua. Everything goes on fine\, the fami
 ly grows\, I step upon a new research field and I even manage to make a 
 'once in a lifetime’ discovery\, and I decide to do the next step in my 
 career and to start an independent research group\, in Padua. Now it's b
 een ten years I run my research group\, I became Associate and then Full
  Professor\, I have fun with science\, the family grew once more. Guess 
 where? In Padua.\n\nThe seminar will be hosted by Dr John Robert Davis
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:Michael Smith Lecture Theatre\, Michael Smith Building\, Manches
 ter
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