BEGIN:VCALENDAR
PRODID:-//Columba Systems Ltd//NONSGML CPNG/SpringViewer/ICal Output/3.3-
 M3//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20191007T092326Z
DTSTART:20191007T130000Z
DTEND:20191007T135000Z
SUMMARY:Joseph Baron - The role of noise and memory effects in developmen
 tal pattern formation
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}wnb-k0xo141
 2-cucdx7
DESCRIPTION:(Room 2.60 Simon Building)\nJoin us for this seminar by Josep
 h Baron (Manchester) as part of the Mathematics in the Life Sciences Ser
 ies.\n\nAbstract:\nMany mechanisms have been developed for the purpose o
 f explaining the formation of the various emergent structures in develop
 mental biology. Two examples are the clock-wavefront mechanism for somit
 e segmentation\, and Turing’s reaction-diffusion equations for spontaneo
 us pattern formation. At their heart\, both of these models involve sets
  of discrete agents interacting with one another in a stochastic manner.
  Often\, however\, the intrinsic noise associated with the individual-ba
 sed nature of the dynamics is neglected in favour of the use of simpler\
 , deterministic equations. Such an approach can ignore important noise-i
 nduced effects such as stochastic patterns\, cycles or waves\, which are
  not captured by deterministic equations and which can be non-negligible
  for the numbers of particles involved in biological systems.\n\nThe tem
 ptation to ignore noise becomes even greater when complicating factors s
 uch as transcriptional delays or anomalous diffusion enter into the mode
 ls. Both of these complications introduce so-called memory effects into 
 the dynamics. The interplay between these memory effects and noise prese
 nts a unique mathematical challenge.\n\nIn this talk\, I will briefly di
 scuss the path integral approach one can use to quantify the noise in in
 dividual-based systems with memory and I will discuss two examples where
  memory is important in a noisy system (alluded to above): delays in the
  gene-regulatory networks related to somite segmentation\, and noise-ind
 uced pattern formation in reaction-diffusion systems with subdiffusion. 
 I will discuss how an interplay between noise and subdiffusion can ameli
 orate the so-called “fine-tuning” issue associated with Turing pattern f
 ormation. I will also discuss how the combination of noise and delay can
  lead to the production of sustained cycles missed by deterministic mode
 ls of the somite segmentation clock\, and discuss the synchronisation\, 
 amplification and increase in coherence of such cycles with the strength
  of “delta-notch” signalling strength between cells.\n\n\nTo subscribe t
 o the mailing list for this event series\, please send an e-mail with th
 e phrase “subscribe math-lifesci-seminar” in the message body to listser
 v@listserv.manchester.ac.uk
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:2.60\, Simon Building\, Manchester
END:VEVENT
END:VCALENDAR