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 M3//EN
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CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20230307T143022Z
DTSTART:20230313T140000Z
DTEND:20230313T150000Z
SUMMARY:Arturo Araujo -- Modelling biological first principles to underst
 and clinical outcomes [IN PERSON]
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}x11k-lecx06
 jj-i55yoi
DESCRIPTION:Join us for this seminar by Arturo Araujo (Roehampton/UCL) as
  part of the North West Seminar Series in Mathematical Biology and Data 
 Sciences. Details of the full series can be found here https://www.cms.l
 ivjm.ac.uk/APMSeminar/\n\nThe talk will be hosted in person in the Simon
  Building\, Room 4.38. For those who cannot attend in person the talk wi
 ll also be streamed via zoom\, please contact carl.whitfield@manchester.
 ac.uk or igor.chernyavsky@manchester.ac.uk for the zoom link\, or sign u
 p to the mailing list.\n\nAbstract: Cell theory\, one of the fundamental
  theories unifying all of biology\, states that all cells come from alre
 ady existing cells\, thus making cell division key to homeostasis. Model
 ling this unifying biological first principle allowed us to examine the 
 complex case of Prostate to Bone Metastasis and its interplay with the b
 one microenvironment. By modelling the heterogeneity of the disease in t
 erms of changes in cell division\, using samples from Mayo Clinic to gen
 erate basic biological data\, we were able to capture the response of th
 e disease to the standard of care in Moffitt Cancer Centre patients. Fur
 thermore\, by utilising differences in cell division under treatment con
 ditions we were able to quantify and forecast the emergence of resistant
  disease. With this\, we aim to discuss the importance of computational 
 modelling\, its caveats and limitations\, and how to take advantage of t
 his to fill gaps in our basic understanding of the disease and improve c
 linical outcomes.\n\nTo subscribe to the mailing list for this event ser
 ies\, please send an e-mail with the phrase “subscribe math-lifesci-semi
 nar” in the message body to listserv@listserv.manchester.ac.uk
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:4.38\, Simon Building\, Manchester
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