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BEGIN:VEVENT
DTSTAMP:20230918T105507Z
DTSTART:20231002T130000Z
DTEND:20231002T140000Z
SUMMARY:Jennfier Tweedy -- Mathematical model of the unconventional drain
 age from the eye [IN PERSON]
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}x1wb-lmorhh
 i8-snb6i7
DESCRIPTION:Join us for this seminar by Jennifer Tweedy (University of Ba
 th) as part of the North West Seminar Series in Mathematical Biology and
  Data Sciences. Details of the full series can be found here https://www
 .cms.livjm.ac.uk/APMSeminar/\n\nThe talk will be hosted in person in the
  Simon Building\, Room 2.61. For those who cannot attend in person the t
 alk will also be streamed via zoom\, please contact carl.whitfield@manch
 ester.ac.uk or igor.chernyavsky@manchester.ac.uk for the zoom link\, or 
 sign up to the mailing list.\n\nAbstract: Aqueous humour is a fluid that
  circulates in the anterior part of the eye to maintain intraocular pres
 sure (IOP) and nourish the tissues. Its outflow is via two main routes: 
 the conventional outflow and the unconventional or uveo-scleral outflow.
   In the unconventional flow the aqueous humour bypasses the conventiona
 l route\, seeping posteriorly through the tissues of the eye and eventua
 lly crossing the sclera and leaving the eye. This flow accounts for a si
 gnificant fraction of the total flow\, and moreover represents a potenti
 al route for delivering drugs to the posterior part of the retina to tre
 at conditions such as age-related macular degeneration. Despite this\, t
 he mechanisms driving the flow have not yet been clearly elucidated. The
  choroid is a dense layer of blood vessels between the retina and the sc
 lera\, and in this research\, we develop a mathematical model to test wh
 ether the uveo-scleral outflow can be explained as primarily a flow thro
 ugh the choroidal tissue driven by the IOP forcing fluid posteriorly thr
 ough the tissue. The flow is additionally affected by the exchange of fl
 uid with blood vessels via Starling forces.\n \nWe model fluid and album
 in flow within the choroidal tissue\, using albumin as a single tracer i
 n the fluid to capture the effects of Starling forces. Choroidal tissue 
 is modelled as axisymmetric shell of porous material\; fluid and albumin
  exchange across blood vessel walls within the choroid and across the sc
 lera (and out of the eye) is governed by the Kedem-Katchalsky equations 
 describing transport through a thin membrane. Flow into the choroid from
  the inner surface (retinal pigment epithelium) is assumed to be prescri
 bed\, with no albumin transport. The narrowness of the choroidal layer a
 llows the equations to be simplified to two second-order coupled ordinar
 y differential equations for fluid and albumin transport\, which may rea
 dily be solved using a numerical scheme. Furthermore\, we allow for the 
 presence of a potential layer that opens between the choroid and the scl
 era\, depending on the pressure.\n \nSolving the model yields the flow a
 nd albumin concentration profiles as a function of position within the c
 horoid\, as well as allowing the exchange with the blood vessels to be f
 ound. The flow exhibits only weak dependency on the IOP\, in agreement w
 ith experimental observations.\n\nTo subscribe to the mailing list for t
 his event series\, please send an e-mail with the phrase “subscribe math
 -lifesci-seminar” in the message body to listserv@listserv.manchester.ac
 .uk
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:2.61\, Simon Building\, Manchester
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