Cell Competition: A mechanism to ensure metabolic fitness during differentiation
| Dates: | 10 November 2015 |
|---|
| Times: | 13:00 - 14:00 |
|---|
| What is it: | Seminar |
|---|
| Organiser: | Faculty of Life Sciences |
|---|
| Who is it for: | University staff, Current University students |
|---|
| Speaker: | Dr Tristan Rodriguez |
|---|
|
|
Part of the FLS Tissue Systems Seminar Series:
Cell-cell interactions govern cell behaviour and survival from the onset of development. When cells with different fitness levels are confronted with each other, a type of cell-cell interaction known as cell competition occurs, resulting in the expansion of the fitter population at the expense of the weaker one. This phenomena is conserved from Drosophila to humans, and has been implicated in a wide variety of processes during development and the maintenance of tissue homeostasis in the adult. Recently we have described that cell competition regulates the fitness of mouse pluripotent stem cells during the first stages of their differentiation. Here we will present data indicating that a key fitness readout is metabolic activity, and that those cells that are less metabolically fit are eliminated by their neighbours. These findings suggest that cell competition could be acting as a general metabolic quality control mechanism, not only during development.
Speaker
Dr Tristan Rodriguez
Organisation: Imperial College
Travel and Contact Information
Find event
Michael Smith Lecture Theatre
Michael Smith Building
Manchester
