BEGIN:VCALENDAR
PRODID:-//Columba Systems Ltd//NONSGML CPNG/SpringViewer/ICal Output/3.3-
 M3//EN
VERSION:2.0
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VEVENT
DTSTAMP:20150508T105140Z
DTSTART:20150519T120000Z
DTEND:20150519T130000Z
SUMMARY:Neutrophil-vessel Wall Interactions in Vivo: Mode\, Mechanisms an
 d Pathogenesis
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}y15-i9fhgaa
 0-oxizyv
DESCRIPTION:Migration of leukocytes to sites of injury or inflammation is
  a crucial component of both innate and adaptive immunity but can also c
 ontribute to the pathogenesis of inflammatory disorders. However despite
  much research there has been a disappointingly slow progress in fruitfu
 l targeting of leukocyte trafficking for development of anti-inflammator
 y drugs\, indicating a need for better understanding of the intricacies 
 of targeted pathways. Within our group we aim to investigate the mechani
 sms of leukocyte transmigration through imaging of inflamed tissues by m
 ultiple methods\, including the application of high resolution confocal 
 intravital microscopy. With this approach we have characterised the prof
 ile and dynamics of leukocyte transmigration through venular walls and a
 s a result have noted previously unreported physiological responses (e.g
 . sub-endothelial cell crawling1) and have identified potential patholog
 ical events such as neutrophil reverse transendothelial cell migration\,
  a response that we have associated with dissemination of systemic infla
 mmation2\,3. Such studies have demonstrated that detailed analysis of le
 ukocyte-vessel wall dynamics are likely to identify novel and disease-sp
 ecific phenomena that could promote a change in thinking towards develop
 ment of new therapeutic strategies4
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:Michael Smith Lecture Theatre\, Michael Smith Building\, Manches
 ter
END:VEVENT
END:VCALENDAR