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BEGIN:VEVENT
DTSTAMP:20241126T093750Z
DTSTART:20241127T130000Z
DTEND:20241127T140000Z
SUMMARY:Louis Gall -- Agent-based modelling of the intestinal epithelium 
 [ONLINE]
UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}y18n-m3y9ka
 o7-xi4wng
DESCRIPTION:Join us for this seminar by Dr Louis Gall (Birmingham) as par
 t of the North West Seminar Series in Mathematical Biology and Data Scie
 nce. More details about the joint series can be found here https://north
 westseminars.great-site.net/ . \n\nThe talk will be hosted by the Univer
 sity of Liverpool and available to watch via zoom. Please contact carl.w
 hitfield@manchester.ac.uk or mdomijan@liverpool.ac.uk for the link\, or 
 sign up to the mailing list.\n\nTitle: Agent-based modelling of the inte
 stinal epithelium\nAbstract: The cells of the intestinal epithelium are 
 produced within invaginations called crypts\, whose constituent cells ca
 refully balance proliferation and differentiation to maintain a function
 al intestinal epithelium. To investigate these dynamics\, we built a mul
 ti-scale agent-based model (ABM) of cells interacting in the intestinal 
 crypt that reproduces the observed dynamic self-organisation necessary f
 or a healthy intestinal epithelium. In our model\, this adaptive homeost
 asis emerges from the interaction of multiple signalling pathways (inclu
 ding simulated Wnt\, Notch\, BMP and RNF43/ZNRF3 pathways) that control 
 the spatial distribution and relative abundance of the different cell ty
 pes found in the crypt. Additionally\, each cell simulates its cell cycl
 e protein network that can be perturbed to simulate the effect of drugs\
 , which then propagates from a single-cell disruption to tissue-scale in
 jury. This framework provides a novel tool for exploring the mechanisms 
 of intestinal homeostasis and their disruption in disease.\n\nTo subscri
 be to the mailing list for this event series\, please send an e-mail wit
 h the phrase “subscribe math-lifesci-seminar” in the message body to lis
 tserv@listserv.manchester.ac.uk
STATUS:TENTATIVE
TRANSP:TRANSPARENT
CLASS:PUBLIC
LOCATION:Online
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