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Cell Signaling by Extracellular Matrix Stiffness

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Dates:19 January 2015
Times:12:00 - 12:00
What is it:Seminar
Organiser:Faculty of Life Sciences
Speaker:Yongho Bae
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  • In group "(FLS) Special Seminars"
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Extracellular matrix (ECM) stiffness is transduced into cellular stiffness, signaling, and changes in cellular behavior. Integrins and several of their associated focal adhesion proteins have been implicated in sensing ECM stiffness. We investigated how an initial sensing event is translated into cellular stiffness and a biologically interpretable signal. We found that a pathway consisting of FAK, Cas, and Rac selectively transduced ECM stiffness into stable cellular stiffness, increased abundance of cyclin D1, and promoted S phase entry. Rac-dependent intracellular stiffening involved its binding partner lamellipodin, a protein that transmits Rac signals to the cytoskeleton during cell migration. Our findings establish that mechanotransduction by a FAK-Cas-Rac-lamellipodin signaling module converts the external information encoded by ECM stiffness into stable cellular stiffness and mechanosensitive cell cycling.

Speaker

Yongho Bae

Role: American Heart Association Postdoctoral Fellow

Organisation: University of Pennsylvania

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Anna Fildes

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anna.fildes@manchester.ac.uk

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