Regulation of gene Expression in testes-how filies make sperm
|Starts:||15:30 8 Apr 2014|
|Ends:||17:00 8 Apr 2014|
|What is it:||Seminar|
|Organiser:||Faculty of Life Sciences|
|Who is it for:||University staff, Current University students|
|Speaker:||Helen White Cooper|
This seminar is part of the Fly Club Seminar Series
The regulation of gene expression clearly pivotal in differentiation of specific cell types. Sperm are arguably the most specialised of all animal cells, and their production requires the expression of a very large number of genes not expressed in any other process. Notably, expression of about 10% of all protein coding genes is specific to, or highly enriched in, testes. We use Drosophila testes as a model to understand how this specialised gene expression programme is controlled.
I will discuss our work describing the testis-specific transcriptional regulator, tMAC, notably, what are the components of this complex, and how to they work together to regulate target genes. I will present recent data indicating that the RNA export pathway is also implicated in activation of testis-specific gene expression, through an interaction with tMAC. Finally I will discuss a new approach we are using to directly determine the chromatin environment at a genome scale in primary spermatocytes.
Helen White Cooper
Organisation: University of Cardiff
Travel and Contact Information
AV Hill Building