Elucidating Mechanisms of Neuropsychiatric Disorders utilizing Genetic Models
|Dates:||29 May 2015|
|Times:||10:00 - 11:30|
|What is it:||Lecture|
|Organiser:||Institute of Brain, Behaviour and Mental Health|
|Who is it for:||Adults, Alumni, Current University students, University staff|
Host: Institute of Brain, Behaviour and Mental Health
Speaker: Anantha Shekhar, M.D., Ph.D, Raymond E. Houk Professor of Psychiatry, and Professor of Neurobiology and Pharmacology and Toxicology, and Associate Dean at the Indiana University School of Medicine
About the event:
Neuropsychiatric disorders have a complex pathophysiology consisting of multi-genetic risk factors that are further amplified with epigenetic, developmental and experiential factors that ultimately induce the disease phenotype. Utilizing rare CNS diseases with known mutations is one of the ways we can elucidate the underlying pathophysiology of these complex disorders and potentially develop new approaches to treating them. Neurofibromatosis type 1 (NF1), a disease caused by mutation in the NF1 gene, is one such rare genetic disorder where a substantial number (~30%) of children also meet the criteria for ASD. The presentation will discuss the results of studies that elucidate the phenotypic features resulting from such gene mutation models, the pathophysiology and neural circuitry that may underlie the expression of such phenotypes, as well as some novel genetic and pharmacological approaches to treating such ASD subtypes.
Dr. Shekhar leads a successful basic and clinical research programs in the areas of neuropsychiatric disorders, funded by the NIH since 1989. His basic research laboratory has developed translational models for several neuropsychiatric disorders, including panic, phobias, anxiety disorders, depression and autism spectrum disorders.
Travel and Contact Information
Lecture Theatre A (3.102)