BEGIN:VCALENDAR PRODID:-//Columba Systems Ltd//NONSGML CPNG/SpringViewer/ICal Output/3.3- M3//EN VERSION:2.0 CALSCALE:GREGORIAN METHOD:PUBLISH BEGIN:VEVENT DTSTAMP:20240830T132108Z DTSTART:20241029T130000Z DTEND:20241029T140000Z SUMMARY:Advances in Biosciences Seminar Series - Dr Pradeepa Madapura \, Blizard Institute\, QMUL London. Title: "Role of histone acetylation pat hways in the regulation of vertebrate genome" UID:{http://www.columbasystems.com/customers/uom/gpp/eventid/}zlv-m0gqshf r-xexonf DESCRIPTION:Introducing the next speaker in October for the Advances in B iosciences Seminar Series\; Dr Pradeepa Madapura \, Blizard Institute\, QMUL London. \nTitle: Role of histone acetylation pathways in the regula tion of vertebrate genome\n\nAbstract: Epigenetic factors including cell -type-specific transcription factors\, writers and readers of histone po sttranslational modifications\, and chromatin remodelling proteins\, pla y an essential role in the controlled tissue-specific regulation of gene expression. Acetylation of histone lysines is one of the most abundant modifications which alters chromatin structure and function. Gene mutati ons that perturb the histone acetylation pathway cause many neurodevelop mental disorders\, warranting further investigation to understand the sp ecific role of the acetylation pathway in the central nervous system. Mo reover\, deciphering the causal role of epigenetic factors in the develo pment of the human nervous system and how the perturbation of the histon e acetylation pathway causes specific disorders is a fundamental challen ge. I will present our lab's recent unpublished work on the role of H4K1 6ac and histone acetylation reader protein – BRD4 in genome regulation. We show histone acetylation pathways can perturb genome function by alte ring the expression of transposable elements in human embryonic stem cel ls and trophoblast lineage. Furthermore\, we show transposable elements that are regulated by this pathway can function as cis-regulatory elemen ts to regulate gene expression in cis. We also show how deregulated hist one acetylations in trophoblast lineage contribute to abnormal placentat ion leading to preeclampsia. Furthermore\, I will also present our work on how mutations in genes encoding histone acetylation pathways can affe ct the development of the nervous system. \n\n\nCareer history\n\n2023 – Reader of Genome Biology\, QMUL\, UK\n2021 – Associate professor (seni or lecturer) at the Queen Mary University of London\, UK\n2018 – Assista nt professor (lecturer) at the Queen Mary University of London\, UK\n201 6 – 2018 Assistant professor (lecturer) at the University of Essex\, Col chester\, UK\n2009 – 2015 Postdoctoral Fellow in the laboratory of Prof Wendy Bickmore\n2004 –2009 PhD\, JNCASR\, Bengaluru\, India\n\nPradeepa Madapura’s research investigates the role of chromatin proteins and hist one modifications in regulating genome functions such as gene expression \, splicing and DNA repair. The highlight of Madapura’s work includes id entifying the novel class of enhancer elements that lack acetylation of histone H3 at lysine 27 (H3K27ac)\, a widely used marker of active enhan cers. (Nature SMB 2023\, Nature Genet 2016\, Genome Res 2013) marks acti ve enhancers. de novo mutations in a key transcriptional regulator BRD4\ , known to function as enhancers and promoters by binding to acetylated histones\, cause a neurodevelopmental disorder called Cornelia de Lange Syndrome (CdLS) (Nature Genet 2018). Recent work shows how chromatin pro tein PSIP1 reduces transcription-associated R-loop accumulation (Nature Comm 2024). Recent unpublished work shows how transposable element expre ssion levels can be used to predict preeclampsia early on in the pregnan cy (In revision\, Patent pending). \n\n\nThe seminar will be hosted by D r Sankari Nagarajan STATUS:TENTATIVE TRANSP:TRANSPARENT CLASS:PUBLIC LOCATION:Michael Smith Lecture Theatre\, Michael Smith Building\, Manches ter END:VEVENT END:VCALENDAR