Material-driven fibronectin fibrillogenesis to engineer the cellular microenvironment
|Starts:||13:00 5 Feb 2014|
|Ends:||14:00 5 Feb 2014|
|What is it:||Seminar|
|Organiser:||Faculty of Life Sciences|
Most cells assemble rich FN matrices via an integrin-dependent process that incorporates FN molecules into matrix fibrils. We have shown this process can occur by simple adsorption of individual FN molecules onto particular surface chemistries – in absence of cells. FN – material interactions would induce exposure of self-assembly sites to drive FN assembly, a process that we named material-driven FN fibrillogenesis.
The resulting FN matrix assembled at the material interface consists of a protein network with enhanced biological activity: it supports cell adhesion, matrix remodeling, and trigger cell differentiation. Moreover, it provides a robust platform to engineer advanced microenvironments in combination with growth factors to tune stem cell differentiation and promote tissue repair.
Organisation: University of Glasgow
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