Celebrating Research Success in FLS Seminar - Membrane Type I-Matrix Metalloproteinase 14 - a pericellular collagenase and tissue architect all rolled up in one
|Starts:||15:00 6 May 2016|
|Ends:||16:00 6 May 2016|
|What is it:||Seminar|
|Organiser:||Faculty of Life Sciences|
|Who is it for:||University staff|
The next seminar in the ‘Celebrating Research Success’ series will be given by Prof Karl Kadler who is a member of the Cell Matrix Biology Research Theme. The seminar is scheduled to take place just prior to FLS Happy Hour to allow discussions and networking to continue after the actual presentation.
Karl’s presentation will be entitled ‘Membrane Type I-Matrix Metalloproteinase 14 - a pericellular collagenase and tissue architect all rolled up in one’ and will focus on one of his publications:
• Taylor SH, Yeung CYC, Kalson NS, Lu Y, Zigrino P, Starborg T, Warwood S, Holmes DF, Canty-Laird EG, Mauch C, Kadler K. (2015). Matrix metalloproteinase 14 is required for fibrous tissue expansion. eLife 2015;10.7554/eLife.09345
Membrane type I-matrix metalloproteinase (MT1-MMP, encoded by mmp14) is well known for its ability to cleave collagen in vitro. However, we were curious why the knockout mouse had fragile tissues and was smaller than its wild-type littermates. It didn’t make sense that missing a major collagenase would result in thin and weak tissues. Even more curious was the fact that the collagenase-resistant mouse (Col-r/r) has the opposite phenotype to the mmp14 knockout mouse and is severely fibrotic, as expected. In this paper we go against dogma and show that MT1-MMP is essential for tissue expansion in the embryo, and catalyses the switch from embryonic to adult fibrous tissue assembly. Without MT1-MMP, the embryo is ‘stuck’ in the embryonic state.
Travel and Contact Information
Michael Smith LT
Michael Smith Building