Guy Blanchard -- 2D and 3D kinematics and mechanics of cell behaviours that drive epithelial morphogenesis [IN PERSON]
| Dates: | 26 February 2024 |
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| Times: | 14:00 - 15:00 |
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| What is it: | Seminar |
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| Organiser: | Department of Mathematics |
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| Who is it for: | University staff, External researchers, Current University students |
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| Speaker: | Guy Blanchard |
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Join us for this seminar by Guy Blanchard (Cambridge) as part of the North West Seminar Series in Mathematical Biology and Data Sciences
The talk will be hosted in person in room 4.63 of the Simon Building. For those who cannot attend in person the talk will also be streamed via zoom, please contact carl.whitfield@manchester.ac.uk or igor.chernyavsky@manchester.ac.uk for the zoom link, or sign up to the mailing list.
Title: 2D and 3D kinematics and mechanics of cell behaviours that drive epithelial morphogenesis
Abstract: Cell shape changes, rearrangements, divisions and gains/losses combine with extrinsic forces to drive epithelial morphogenesis. I will provide a brief overview of our understanding and ability to quantify cell behavioural kinematics and mechanics in epithelia, with particular reference to embryonic epithelia in the fruit-fly Drosophila.
I will then focus on the quantification of cell intercalation during axis extension, highlighting the supracellular organisation of contractility that drives convergence-extension movements.
My third focus will be on the mechanisms of how mechanics and antero-posterior (AP) patterning combine to orient cell divisions in the plane (OCD). We show that stress anisotropy influences the OCD by imposing cell elongation in metaphase, despite mitotic rounding and over-riding interphase cell elongation. Alongside mechanical cues, there is a tissue-wide bias of the mitotic spindle orientation towards AP-patterned planar polarised Myosin-II.
Finally, I will argue that 2D studies are often insufficient and will introduce ways in which we are approaching epithelial kinematics and mechanics in 3D.
To subscribe to the mailing list for this event series, please send an e-mail with the phrase “subscribe math-lifesci-seminar” in the message body to listserv@listserv.manchester.ac.uk
Speaker
Guy Blanchard
Role: Senior Research Associate
Organisation: University of Cambridge
Travel and Contact Information
Find event
4.63
Simon Building
Manchester
