Advances in Biosciences Seminar Series - Dr David Gershlick, University of Cambridge
| Dates: | 11 November 2025 |
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| Times: | 13:00 - 14:00 |
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| What is it: | Seminar |
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| Organiser: | Faculty of Biology, Medicine and Health |
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| Who is it for: | University staff |
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| Speaker: | David Gershlick |
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Join the Division of Molecular and Cellular Function (MCF) for the Advances in Biosciences Seminar Series, the speaker is Dr David Gershlick, University of Cambridge.
Hosted by Dr Alex Davies.
Title: “The trafficking of membrane proteins to the cell surface”
Abstract: Secreted proteins underpin myriad physiological processes, ranging from immunity and inter-cellular signalling to dynamic remodelling of the extracellular matrix. After biosynthesis and post-translational modification, these cargoes must traverse the Golgi apparatus, where they are selectively sorted into carriers bound for the plasma membrane or the extracellular milieu. The molecular logic governing this journey remains incompletely defined.
Here, we integrate super-resolution microscopy with transient CRISPR-mediated knock-outs, quantitative pulse-chase trafficking assays and designer fluorescent cargo constructs to dissect the spatiotemporal rules of Golgi exit. Our data uncover novel machinery and mechanisms for Golgi export. Collectively, these findings refine the conceptual framework of secretory-pathway organisation and provide a predictive toolkit for manipulating protein secretion in health and disease.
Speaker
David Gershlick
Role: Dr
Organisation: University of Cambridge
Travel and Contact Information
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Michael Smith Lecture Theatre
Michael Smith Building
Manchester
