Samir Ghadiali -- Translational Applications of Mathematical and Computational Modeling in Respiratory and Critical Care Medicine [IN PERSON]
| Dates: | 9 December 2024 |
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| Times: | 14:00 - 15:00 |
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| What is it: | Seminar |
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| Organiser: | Department of Mathematics |
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| Who is it for: | University staff, External researchers, Current University students |
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| Speaker: | Samir Ghadiali |
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Join us for this seminar by Samir Ghadiali (Ohio) as part of the North West Seminar Series in Mathematical Biology and Data Sciences. More details about the joint series can be found here https://northwestseminars.great-site.net/ .
The talk will be hosted in person in room 1.34 of the Simon Building. For those who cannot attend in person the talk will also be streamed via zoom, please contact carl.whitfield@manchester.ac.uk or igor.chernyavsky@manchester.ac.uk for the zoom link, or sign up to the mailing list.
Title: Translational Applications of Mathematical and Computational Modeling in Respiratory and Critical Care Medicine
Abstract: The global COVID-19 pandemic has highlighted the lethality and morbidity associated with infectious respiratory diseases. These diseases can lead to a devastating syndrome known as the acute respiratory distress syndrome (ARDS) where bacterial/viral infections cause excessive lung inflammation, pulmonary edema, and severe hypoxemia (shortness of breath). Although ARDS patients require artificial mechanical ventilation, the complex biofluid and biomechanical forces generated by the ventilator exacerbates lung injury leading to high mortality. My group has used mathematical and computational modeling to both characterize the complex mechanics of lung injury during ventilation and to identify novel ways to prevent injury at the cellular level. We have used in-vitro and in-vivo studies to validate our mathematical predictions and have used engineering tools to understand the biological consequences of the mechanical forces generated during ventilation. In this talk I will specifically describe how our mathematical/computational approach has led to novel cytoskeletal based therapies and how coupling mathematics and molecular biology has led to the discovery of a gene regulatory mechanisms that can minimize ventilation induced lung injury. I will also describe how we are currently using mathematical modeling to optimize nanotechnology-based gene/drug delivery systems that enhance the lung’s native regulatory responses and thereby prevent lung injury during ARDS.
Bio: Samir Ghadiali is Professor and Chair/Head of the Department of Biomedical Engineering at the Ohio State University (OSU) and a Professor of Pulmonary and Critical Care Medicine at the OSU Wexner Medical Center. Dr. Ghadiali is a Fellow of the American Institute of Medical and Biological Engineering, a Fellow of the Biomedical Engineering Society and is a Parker B. Francis Fellow in Pulmonary Research. He is a member of the Davis Heart & Lung Research Institute and the Biophysics Graduate Program at OSU, and his internationally recognized research program uses biomedical engineering tools to develop novel diagnostic platforms and drug/gene therapies for cardiovascular and respiratory disorders. His research has been funded by the National Science Foundation, National Institutes of Health, the American Heart Association, and the United States Department of Defense and he has mentored over 35 pre-doctoral and post-doctoral trainees who have gone on to successful academic, industrial and research careers.
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Speaker
Samir Ghadiali
Role: Professor
Organisation: Ohio State University
Travel and Contact Information
Find event
1.34
Simon Building
Manchester
