Martin Falcke -- Constitutive relations of cell motility and Ca2+ signalling and the role of noise [IN PERSON]
| Dates: | 12 October 2026 |
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| Times: | 14:00 - 15:00 |
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| What is it: | Seminar |
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| Organiser: | Department of Mathematics |
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| Who is it for: | University staff, External researchers, Current University students |
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| Speaker: | Martin Falcke |
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Join us for this seminar by Martin Falcke (Berlin) as part of the Maths in the Life Sciences seminar series (and the online North West Seminar Series in Mathematical Biology and Data Sciences in collaboration with Liverpool Universities).
Title: Constitutive relations of cell motility and Ca2+ signalling and the role of noise
Abstract: Cell variability and noisy behavior challenge the quantitative characterization of cell behavior by temporal or population averages. Constitutive relations offer an alternative. They are the quantitative definition of a physical object. Applied to cells, they quantify cell behavior or the response to external conditions.
Cytosolic Ca2+ is a second messenger used by all eukaryotic cells. The motion of cells is essential for embryonic development, wound healing, immune response, and tumor metastasis. Both of these basic cell functions exhibit large cell-to-cell variability. Noise drives subcellular and cellular Ca2+ signals. It drives also the transitions of morphodynamic states of motile cells and shapes the speed-persistence time relation.
We describe quantitative characterizations of both Ca2+ signalling and cell motility on 1dimensional lanes. On that basis, we suggest to define cell behavior by constitutive relations which capture cell variability. The constitutive adhesion-speed relation of motile cells can be perceived as stationary states of a deterministic system. The constitutive relations describing dynamics are all intrinsically related to noise.
The talk will be also be streamed via Teams, please contact carl.whitfield@manchester.ac.uk or igor.chernyavsky@manchester.ac.uk for the link, or sign up to the mailing list.
To subscribe to the mailing list for this event series, please send an e-mail with the phrase “subscribe math-lifesci-seminar” in the message body to listserv@listserv.manchester.ac.uk
Speaker
Martin Falcke
Role: Professor
Organisation: Max Delbrück Center (Berlin)
Travel and Contact Information
Find event
6.53 (Niels Bohr Common Room)
Schuster Building
Manchester
