Louis Gall -- Agent-based modelling of the intestinal epithelium [ONLINE]
| Dates: | 27 November 2024 |
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| Times: | 13:00 - 14:00 |
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| What is it: | Seminar |
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| Organiser: | Department of Mathematics |
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| Who is it for: | University staff, External researchers, Current University students |
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| Speaker: | Louis Gall |
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Join us for this seminar by Dr Louis Gall (Birmingham) as part of the North West Seminar Series in Mathematical Biology and Data Science. More details about the joint series can be found here https://northwestseminars.great-site.net/ .
The talk will be hosted by the University of Liverpool and available to watch via zoom. Please contact carl.whitfield@manchester.ac.uk or mdomijan@liverpool.ac.uk for the link, or sign up to the mailing list.
Title: Agent-based modelling of the intestinal epithelium
Abstract: The cells of the intestinal epithelium are produced within invaginations called crypts, whose constituent cells carefully balance proliferation and differentiation to maintain a functional intestinal epithelium. To investigate these dynamics, we built a multi-scale agent-based model (ABM) of cells interacting in the intestinal crypt that reproduces the observed dynamic self-organisation necessary for a healthy intestinal epithelium. In our model, this adaptive homeostasis emerges from the interaction of multiple signalling pathways (including simulated Wnt, Notch, BMP and RNF43/ZNRF3 pathways) that control the spatial distribution and relative abundance of the different cell types found in the crypt. Additionally, each cell simulates its cell cycle protein network that can be perturbed to simulate the effect of drugs, which then propagates from a single-cell disruption to tissue-scale injury. This framework provides a novel tool for exploring the mechanisms of intestinal homeostasis and their disruption in disease.
To subscribe to the mailing list for this event series, please send an e-mail with the phrase “subscribe math-lifesci-seminar” in the message body to listserv@listserv.manchester.ac.uk
Speaker
Louis Gall
Role: SMQB Centre Fellow
Organisation: University of Birmingham
Travel and Contact Information
