BSI Manchester Immunology Group Seminar Series: Dr David Bending, University of Birmingham. Location: MS Lecture Theatre, Michael Smith Building
| Dates: | 13 February 2025 |
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| Times: | 12:00 - 13:00 |
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| What is it: | Seminar |
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| Organiser: | School of Biological Sciences |
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| How much: | Free |
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| Who is it for: | University staff, External researchers, Adults, Alumni, Current University students |
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| Speaker: | Dr David Bending |
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Talk title: Regulation of NFAT signalling in CD4+ T cells
Brief lab biography:
Our research focuses on how TCR signalling regulates T cell biology. My lab has interests in understanding how immunotherapy can alter T cell activation and identify favourable T cell signatures of therapy responders. We have developed cutting-edge TCR signalling research tools, such as the Timer rapidly expressed in lymphocytes (Tempo) mice, to study T cell activation. Recent major findings are i) the discovery of the “TCR.strong” signalling signature, which is a hallmark of effective T cell responses to anti-PD1 immunotherapy; and ii) that anti-Lag3 and anti-PD-1 combination therapy drives distinct NFAT-dependent TCR signalling programmes. Our vision is that through gaining a deeper mechanistic understanding of checkpoint biology, we can use this knowledge to inform precision medicine strategies.
Speaker
Dr David Bending
Organisation: Univerity of Birmingham
Travel and Contact Information
Find event
Michael Smith Lecture Theatre
Michael Smith Building
Manchester
