Developmental and functional heterogeneity of monocytes
|Starts:||13:00 31 May 2018|
|Ends:||14:00 31 May 2018|
|What is it:||Seminar|
|Organiser:||Faculty of Biology, Medicine and Health|
|Who is it for:||University staff|
Gene Expression, Chromatin and Signalling Seminar
Monocytes are circulating, short-lived mononuclear phagocytes, which in mice and man comprise two main subpopulations. Murine Ly6C+ monocytes display developmental plasticity and are recruited to complement tissue-resident macrophages and dendritic cells on demand. Murine vascular Ly6C- monocytes patrol the endothelium, act as scavengers and support vessel wall repair. Our data indicate that Ly6C+ monocytes represent an unstable cell population with a molecular and epigenetic default differentiation potential towards Ly6C- monocytes. However, even though Ly6C+ cells seem to represent an a priori developmental stage, they are equipped with unique functional properties such as tissue infiltration and pro-inflammatory activity, which cannot be acquired by Ly6C- monocytes. In the seminar we will discuss the fate and function of monocytes under homeostatic as well pathological conditions.
hosted by: Kim Mace
Alex will be here from 9am-5pm on the 31st, so please let Kim know if you’d like to meet with him.
Organisation: Max Delbrück Centre for Molecular Medicine, Berlin
Travel and Contact Information
Michael Smith Lecture Theatre
Michael Smith Building