Developmental and functional heterogeneity of monocytes
| Dates: | 31 May 2018 |
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| Times: | 13:00 - 14:00 |
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| What is it: | Seminar |
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| Organiser: | Faculty of Biology, Medicine and Health |
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| Who is it for: | University staff |
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| Speaker: | Alexander Mildner |
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Gene Expression, Chromatin and Signalling Seminar
Abstract:
Monocytes are circulating, short-lived mononuclear phagocytes, which in mice and man comprise two main subpopulations. Murine Ly6C+ monocytes display developmental plasticity and are recruited to complement tissue-resident macrophages and dendritic cells on demand. Murine vascular Ly6C- monocytes patrol the endothelium, act as scavengers and support vessel wall repair. Our data indicate that Ly6C+ monocytes represent an unstable cell population with a molecular and epigenetic default differentiation potential towards Ly6C- monocytes. However, even though Ly6C+ cells seem to represent an a priori developmental stage, they are equipped with unique functional properties such as tissue infiltration and pro-inflammatory activity, which cannot be acquired by Ly6C- monocytes. In the seminar we will discuss the fate and function of monocytes under homeostatic as well pathological conditions.
hosted by: Kim Mace
Alex will be here from 9am-5pm on the 31st, so please let Kim know if you’d like to meet with him.
Speaker
Alexander Mildner
Role: Dr
Organisation: Max Delbrück Centre for Molecular Medicine, Berlin
Travel and Contact Information
Find event
Michael Smith Lecture Theatre
Michael Smith Building
Manchester
