Professor Dirk Linke, Department of Biosciences, University of Oslo, Norway. Hosted by Dr Christos Pliotas
| Dates: | 30 September 2024 |
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| Times: | 13:00 - 14:00 |
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| What is it: | Seminar |
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| Organiser: | Faculty of Biology, Medicine and Health |
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| Who is it for: | University staff |
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| Speaker: | Professor Dirk Linke |
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Please join us for a seminar hosted by Dr Christos Pliotas.
Title: "Autotransporter adhesins in Gram-negative bacteria: structure, function, evolution"
Summary: Autotransporters - or Type V secretion systems - are simple secretion systems that translocate surface proteins across the outer membrane of Gram-negative bacteria. Mostly, these proteins then remain anchored in the membrane and fulfil key functions in pathogenesis. Some of the major adhesins of Gram-negative human pathogens are part of this large family, mediating attachment to host cells and/or initiating biofilm formation.
Over the last years, my group has been working on both the translocation mechanism across the membrane, and the binding functions of select type-V-secreted adhesins. We use a broad range of methods from infection biology to bioinformatics and NMR. Our model systems include both human and animal pathogens - we try to learn from the similarities and differences of their adhesin virulence factors, aiming to understand what defines host specificity, and how adhesion could be used as a target for new antibacterial drugs.
Speaker
Professor Dirk Linke
Role: Professor
Organisation: University of Oslo, Norway
Travel and Contact Information
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Michael Smith Lecture Theatre
Michael Smith Building
Manchester
