Material-driven fibronectin fibrillogenesis to engineer the cellular microenvironment
| Dates: | 5 February 2014 |
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| Times: | 13:00 - 14:00 |
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| What is it: | Seminar |
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| Organiser: | Faculty of Life Sciences |
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| Speaker: | Manuel Salmeron-Sanchez |
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Most cells assemble rich FN matrices via an integrin-dependent process that incorporates FN molecules into matrix fibrils. We have shown this process can occur by simple adsorption of individual FN molecules onto particular surface chemistries – in absence of cells. FN – material interactions would induce exposure of self-assembly sites to drive FN assembly, a process that we named material-driven FN fibrillogenesis.
The resulting FN matrix assembled at the material interface consists of a protein network with enhanced biological activity: it supports cell adhesion, matrix remodeling, and trigger cell differentiation. Moreover, it provides a robust platform to engineer advanced microenvironments in combination with growth factors to tune stem cell differentiation and promote tissue repair.
Speaker
Manuel Salmeron-Sanchez
Role: Professor
Organisation: University of Glasgow
Travel and Contact Information
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1.006
AV Hill Building
Manchester
