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Redox Regulation of Chondrocyte Integrin Signaling and Osteoarthritis

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Dates:6 April 2016
Times:13:00 - 14:00
What is it:Seminar
Organiser:Faculty of Life Sciences
Who is it for:University staff
Speaker:Richard Loeser
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  • In category "Seminar"
  • In group "(FLS) Special Seminars"
  • By Faculty of Life Sciences

Richard is Director of Basic and Translational Research in the Thurston Arthritis Research Center at Chapel Hill, North Carolina.

Abstract : Osteoarthritis results from degradation of joint tissues including the articular cartilage. Chondrocytes are the only cell type present in cartilage and are responsible for both synthesis and degradation of the cartilage matrix. As the cartilage ECM is degraded, fragments of ECM proteins, including fibronectin fragments that bind the ?5?1 integrin are generated. Unlike intact fibronectin, fibronectin fragments activate cell signaling pathways that upregulate expression of a host of MMPs, cytokines, and chemokines that promote progressive matrix destruction in a positive feedback fashion. Our most recent studies have focused on the redox regulation of chondrocyte signaling through oxidative posttranslational modification of reactive cysteine residues in specific signaling proteins through a process known as protein sulfenylation. These studies are helping to identify key steps in fibronectin fragment-induced signaling that will lead to new targets to stop the progressive destruction of cartilage and other joint tissues in OA.

Speaker

Richard Loeser

Role: Director of Basic and Translational Research

Organisation: Thurston Arthritis Research Center at Chapel Hill, North Carolina

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