Manchester Infection Seminar Series 2019 - Unexpected roles for herpes simplex virus structural proteins in RNA metabolism
|Dates:||8 March 2019|
|Times:||12:00 - 13:00|
|What is it:||Seminar|
|Organiser:||Faculty of Biology, Medicine and Health|
|Who is it for:||University staff, Adults|
Professor Gillian Elliott
Dept of Microbial Sciences, University of Surrey
Cell biology of herpes simplex virus (HSV) infection
Professor Gill Elliott will join us on Friday 12 noon (AV Hill 1.006) to deliver a talk: Unexpected roles for herpes simplex virus structural proteins in RNA metabolism
Gill is a serving member of the MRC Infections & Immunity Board (IIB) whose research focuses on the cell biology of herpes simplex virus (HSV) infection and uses a combination of live cell studies, fluorescently tagged viruses, virus genetics, siRNA depletion, and biochemical assays to pinpoint critical molecules - both viral and cellular - as potential targets for antiviral intervention. If you would like to meet with Gill, or join us for lunch on Friday, please contact Elaine Bignell directly firstname.lastname@example.org and use the header Gill Elliott appointment.
Unlike the majority of human viruses, HSV establishes lifelong latent infection (in sensory neurons), and is reactivated periodically to produce new disease and infectivity. Reactivated HSV has a major impact on human health throughout the world. Apart from oral cold sores and genital herpes, reactivated HSV is also the leading cause of infectious blindness in the developed world, and the major viral cause of encephalitis that can often be fatal.
Like all viruses, HSV exploits pre-existing cellular activities in its replication. Gill’s work aims to determine how HSV hijacks cellular machinery to coordinate the assembly of its large, complex particles, with a particular interest in how HSV utilises the cellular secretory pathway to direct the process of assembly; how the individual virus structural molecules interact as the new particle is built; where in the cell these interactions occur; and which cellular molecules are crucial to this process.
Travel and Contact Information
AV Hill Building