Centre for Biostatistics Seminar - Approaches to modelling haematoma resolution
| Dates: | 10 September 2018 |
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| Times: | 14:00 - 15:00 |
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| What is it: | Seminar |
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| Organiser: | Faculty of Biology, Medicine and Health |
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| Who is it for: | University staff |
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| Speaker: | Calvin Heal |
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The next Centre for Biostatistics Seminar talk will take place on 10 September, with speaker, Calvin Heal.
Abstract:
Intracerebral haemorrhage (ICH), bleeding within the brain tissue, is a particularly harmful form of stroke. The size of the bleed (haematoma) and how quickly it subsequently clears determines how much surrounding tissue is damaged and the patient’s functional outcome. Experimental evidence suggests that the immune system facilitates this haematoma clearance.
In our dataset, 274 patients with ICH had numerous CT scans up to and beyond day 30, whereby most patients haematomas had largely resolved. We aimed to determine whether any patient characteristics were associated with the rate of resolution. Determining the rate of resolution is complicated by the concurrence of two processes following stroke onset: expansion of the haematoma for the first couple of days after and the immune systems continuous hypothesised attempts to clear the haematoma. The overlapping physiological processes and variability in number of CT scans available for each patient made for an interesting challenge in modelling the data. Our various approaches are outlined before we explain how enlisting the help of a department more familiar with pharmacokinetic modelling problems helped us reach our conclusions.
Speaker
Calvin Heal
Role: Research Assistant
Organisation: School of Health Sciences
Travel and Contact Information
Find event
G306A
Jean McFarlane Building
Oxford Rd
Manchester
