Centre for Biostatistics Seminar: Identification of causal genes of immune-mediated diseases using statistical colocalisation
|Dates:||14 December 2015|
|Times:||14:30 - 14:30|
|What is it:||Seminar|
|Organiser:||Institute of Population Health|
|Who is it for:||Current University students, University staff|
Host: Institute of Population Health
About the event:
The next Centre for Biostatistics seminar is taking place Monday 14th December at 2.30 pm in G306B Jean McFarlane Building. The speaker will be Hui Guo.
Title: From association to causation: identification of causal genes of immune-mediated diseases using statistical colocalisation
Autoimmune diseases, for example, type 1 diabetes and rheumatoid arthritis, are long-term diseases due to abnormal immune responses of the bodies. To date, hundreds of disease-associated regions have been successfully identified through genome-wide association studies (GWAS). Searching for shared causal signals becomes an important part of research in genetics. Furthermore, the mechanisms of these associations mediated by genetic regulation is partially understood.
Statistical colocalisation is a way to address such issues by integrating results from different studies, under certain assumptions. Hui Guo will give an overview of colocalisation methods where only summary statistics are required. In particular, the talk will focus on a Bayesian approach using approximate Bayes factor. Two examples will be discussed for applications: integrated analysis of disease association and gene expression, and of associations of various autoimmune diseases.
Role: Lecturer in Biostatistics
Organisation: Centre for Biostatistics, Institute of Population Health
Travel and Contact Information
Jean McFarlane Building