Events at The University of Manchester
  • University home
  • Events
  • Home
  • Exhibitions
  • Conferences
  • Lectures and seminars
  • Performances
  • Events for prospective students
  • Sustainability events
  • Family events
  • All Events

Centre for Biostatistics Seminar: Identification of causal genes of immune-mediated diseases using statistical colocalisation

Dates:14 December 2015
Times:14:30 - 14:30
What is it:Seminar
Organiser:Institute of Population Health
Who is it for:Current University students, University staff
Speaker:Hui Guo
See travel and contact information
Add to your calendar

Other events

  • In category "Seminar"
  • By Institute of Population Health

Host: Institute of Population Health

About the event:

The next Centre for Biostatistics seminar is taking place Monday 14th December at 2.30 pm in G306B Jean McFarlane Building. The speaker will be Hui Guo.

Title: From association to causation: identification of causal genes of immune-mediated diseases using statistical colocalisation

Abstract:

Autoimmune diseases, for example, type 1 diabetes and rheumatoid arthritis, are long-term diseases due to abnormal immune responses of the bodies. To date, hundreds of disease-associated regions have been successfully identified through genome-wide association studies (GWAS). Searching for shared causal signals becomes an important part of research in genetics. Furthermore, the mechanisms of these associations mediated by genetic regulation is partially understood.

Statistical colocalisation is a way to address such issues by integrating results from different studies, under certain assumptions. Hui Guo will give an overview of colocalisation methods where only summary statistics are required. In particular, the talk will focus on a Bayesian approach using approximate Bayes factor. Two examples will be discussed for applications: integrated analysis of disease association and gene expression, and of associations of various autoimmune diseases.

Speaker

Hui Guo

Role: Lecturer in Biostatistics

Organisation: Centre for Biostatistics, Institute of Population Health

Travel and Contact Information

Find event

G306B
Jean McFarlane Building
Oxford Rd
Manchester

Contact event

Wendy Lamb

wendy.lamb@manchester.ac.uk

Contact us

  • +44 (0) 161 306 6000

Find us

The University of Manchester
Oxford Rd
Manchester
M13 9PL
UK

Connect with the University

  • Facebook page for The University of Manchester
  • X (formerly Twitter) page for The University of Manchester
  • YouTube page for The University of Manchester
  • Instagram page for The University of Manchester
  • TikTok page for The University of Manchester
  • LinkedIn page for The University of Manchester

  • Privacy /
  • Copyright notice /
  • Accessibility /
  • Freedom of information /
  • Charitable status /
  • Royal Charter Number: RC000797
  • Close menu
  • Home
    • Featured events
    • Today's events
    • The Whitworth events
    • Manchester Museum events
    • Jodrell Bank Discovery Centre events
    • Martin Harris Centre events
    • The John Rylands Library events
    • Exhibitions
    • Conferences
    • Lectures and seminars
    • Performances
    • Events for prospective students
    • Sustainability events
    • Family events
    • All events